Mechanical Stability Affects Angiogenesis During Early Fracture Healing
نویسندگان
چکیده
منابع مشابه
Effect of mechanical stability on fracture healing--an update.
The effects of mechanical stability and mechanical stimulation have been studied extensively in vivo using a variety of animal models and stimulators. Early results indicated that stimulation does not significantly contribute to fracture healing. Lately, however, more rigid external stimulators that withstand increased callus formation have identified a contribution of mechanical stimulation in...
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Among other stressors, age and mechanical constraints significantly influence regeneration cascades in bone healing. Here, our aim was to identify genes and, through their functional annotation, related biological processes that are influenced by an interaction between the effects of mechanical fixation stability and age. Therefore, at day three post-osteotomy, chip-based whole-genome gene expr...
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G protein coupled receptor kinase 2 (GRK2) interacting protein-1 (GIT1), is a scaffold protein that plays an important role in angiogenesis and osteoclast activity. We have previously demonstrated that GIT1 knockout (GIT1 KO) mice have impaired angiogenesis and dysregulated osteoclast podosome formation leading to a reduction in the bone resorbing ability of these cells. Since both angiogenesis...
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Local insulin delivery has been shown to improve osseous healing in diabetic animals. The purpose of this study was to quantify the effects of local intramedullary delivery of saline or Ultralente insulin (UL) on various fracture healing parameters using an in vivo non-diabetic BB Wistar rat model. Quantitation of local insulin levels showed a rapid release of insulin from the fractured femora,...
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BACKGROUND Fibromodulin (FMOD) plays a critical role in the wound-healing process. Our previous studies revealed that FMOD deficiency led to marked alterations in adult wound healing characterized by delayed dermal cell migration, postponed wound closure, and increased scar formation, all accompanied by impeded angiogenesis. Therefore, the aim of this study was to reveal the effect of FMOD on a...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Trauma
سال: 2011
ISSN: 0890-5339
DOI: 10.1097/bot.0b013e31822511e0